Table 1 Parameter values used in the computer simulations. (Note that the dimension of λi, (i = 0, 1,..., N) is cm-2 s-1, but it becomes s-1 when dimensioness number densities are used).
From: A continuum mathematical model of endothelial layer maintenance and senescence
Parameter | Value | Description |
|---|---|---|
N | 50 | number of generations from progenitor to senescence |
D | 10-8 cm2 s-1 | diffusion coefficient of dead cells |
k 0 | 0 s-1 | death rate coefficient of progenitor cells |
k N | 0.6 × 10-7 s-1 | death rate coefficient of senescent cells |
k i (i = 1,..., N - 1) | (kN + 1)i/N - 1 s-1 | death rate coefficient of cells of age i |
λ 0 | 0.4 × 10-4 s-1 | division rate constant of progenitor cells |
λ N | 0 s-1 | division rate constant of senescent cells |
λ i (i = 1,..., N - 1) | (λ0 + 1)(N-i)/N - 1 s-1 | division rate constant of cells at age i |
γ | 10-9 - 10-8 day-1 ≈ (10-9 - 10-8) × 10-5 s-1 | homing rate coefficient of progenitor cells |
δ | 6 × 10-7 s-1 | clearance rate coefficient of dead cells |