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Table 2 Positive-negative ratios of charged amino acids.

From: Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)

 

Start-end

D%

E%

H%

K%

R%

D+E%

K+R%

H+K+R%

( K + R ) ( D + E ) MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabcIcaOiabbUealjabgUcaRiabbkfasjabcMcaPaqaaiabcIcaOiabbseaejabgUcaRiabbweafjabcMcaPaaaaaa@364C@

( H + K + R ) ( D + E ) MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabcIcaOiabbIeaijabgUcaRiabbUealjabgUcaRiabbkfasjabcMcaPaqaaiabcIcaOiabbseaejabgUcaRiabbweafjabcMcaPaaaaaa@3845@

ABCC5-TMD1

179 – 454

1.1

4.3

0.7

5.4

4.3

5.4

9.7

10.4

1.7

1.8

ABCC5-TMD2

848–1147

3.7

2.3

2.3

2.7

5.3

6

8

10.3

1.3

1.7

ABCC5, both TMDs

         

1.5

1.8

ABCB1-TMD1

52–346

3.7

5.1

1.4

4.7

3.4

8.8

8.1

9.5

0.9

1.1

ABCB1-TMD2

711–994

2.8

3.5

1.1

4.9

4.2

6.3

9.1

10.2

1.4

1.6

ABCB1, both TMDs

         

1.1

1.4

  1. Positive-negative ratios of charged amino acids. The percentages % of aspartate (D), glutamate (E), histidine (H), lysine (K), and arginine (R), and positive-negative ratios of charged amino acids in ABCB1-TMD1, ABCB1-TMD2, ABCC5-TMD1, and ABCC5-TMD2. The positive-negative ratio of amino acids is higher in the ABCC5 TMDs (1.5, 1.8 including histidine) than in the ABCB1 TMDs (1.1, 1.4 including histidine).
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Theoretical Biology and Medical Modelling

ISSN: 1742-4682