Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)

Table 2 Positive-negative ratios of charged amino acids.

	Start-end	D%	E%	H%	K%	R%	D+E%	K+R%	H+K+R%	$(K + R) (D + E) MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabcIcaOiabbUealjabgUcaRiabbkfasjabcMcaPaqaaiabcIcaOiabbseaejabgUcaRiabbweafjabcMcaPaaaaaa@364C@$	$(H + K + R) (D + E) MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabcIcaOiabbIeaijabgUcaRiabbUealjabgUcaRiabbkfasjabcMcaPaqaaiabcIcaOiabbseaejabgUcaRiabbweafjabcMcaPaaaaaa@3845@$
ABCC5-TMD1	179 – 454	1.1	4.3	0.7	5.4	4.3	5.4	9.7	10.4	1.7	1.8
ABCC5-TMD2	848–1147	3.7	2.3	2.3	2.7	5.3	6	8	10.3	1.3	1.7
ABCC5, both TMDs										1.5	1.8
ABCB1-TMD1	52–346	3.7	5.1	1.4	4.7	3.4	8.8	8.1	9.5	0.9	1.1
ABCB1-TMD2	711–994	2.8	3.5	1.1	4.9	4.2	6.3	9.1	10.2	1.4	1.6
ABCB1, both TMDs										1.1	1.4

Positive-negative ratios of charged amino acids. The percentages % of aspartate (D), glutamate (E), histidine (H), lysine (K), and arginine (R), and positive-negative ratios of charged amino acids in ABCB1-TMD1, ABCB1-TMD2, ABCC5-TMD1, and ABCC5-TMD2. The positive-negative ratio of amino acids is higher in the ABCC5 TMDs (1.5, 1.8 including histidine) than in the ABCB1 TMDs (1.1, 1.4 including histidine).