Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Positive-negative ratios of charged amino acids.

From: Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)

  Start-end D% E% H% K% R% D+E% K+R% H+K+R% ( K + R ) ( D + E ) MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabcIcaOiabbUealjabgUcaRiabbkfasjabcMcaPaqaaiabcIcaOiabbseaejabgUcaRiabbweafjabcMcaPaaaaaa@364C@ ( H + K + R ) ( D + E ) MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabcIcaOiabbIeaijabgUcaRiabbUealjabgUcaRiabbkfasjabcMcaPaqaaiabcIcaOiabbseaejabgUcaRiabbweafjabcMcaPaaaaaa@3845@
ABCC5-TMD1 179 – 454 1.1 4.3 0.7 5.4 4.3 5.4 9.7 10.4 1.7 1.8
ABCC5-TMD2 848–1147 3.7 2.3 2.3 2.7 5.3 6 8 10.3 1.3 1.7
ABCC5, both TMDs           1.5 1.8
ABCB1-TMD1 52–346 3.7 5.1 1.4 4.7 3.4 8.8 8.1 9.5 0.9 1.1
ABCB1-TMD2 711–994 2.8 3.5 1.1 4.9 4.2 6.3 9.1 10.2 1.4 1.6
ABCB1, both TMDs           1.1 1.4
  1. Positive-negative ratios of charged amino acids. The percentages % of aspartate (D), glutamate (E), histidine (H), lysine (K), and arginine (R), and positive-negative ratios of charged amino acids in ABCB1-TMD1, ABCB1-TMD2, ABCC5-TMD1, and ABCC5-TMD2. The positive-negative ratio of amino acids is higher in the ABCC5 TMDs (1.5, 1.8 including histidine) than in the ABCB1 TMDs (1.1, 1.4 including histidine).