Parenchymal Cell Agent (PC) Zone 1
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Functional tissue cells
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(Parenchymal-kine 1) PK1
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Stress factors such as Heat Shock Proteins [66], Uric Acid [67], and Chemerin [68], chemokines such as CX3CL1, CCL3, CCL5, CCL6
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Virus
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Virus particles
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Apoptotic bodies
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Apoptotic bodies or dead cells associated with programmed cell death
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Necrosis factors
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Cell fragments associated with death by necrosis
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Dendritic Cell Agent (DC1, DC2) Zones 1, 2
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Tissue surveillance, antigen presentation, INNATE immunity
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(Mono-kine 1) MK1
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IL-12, IL-8 (CXCL8) [69], CCL3, CCL4, CCL5, CXCL9, CXCL10, CXCL11
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(Mono-kine 2) MK2
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IL-10, CCL1, CCL17, CCL22, CCL11, CCL24, CCL26
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Macrophage Agent (MΦ1, MΦ2)Zone 1
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Scavenging of dead cell debris, antigen presentation, INNATE immunity
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MK1
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IL-12, IL-8 (CXCL8), CCL3, CCL4, CCL5, CXCL9, CXCL10, CXCL11
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MK2
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IL-10, CCL1, CCL17, CCL22, CCL11, CCL24, CCL26
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T Cell Agent (T, T1, T2) Zones 2,3,1
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T HELPER lymphocytes, cell-mediated, ADAPTIVE immunity
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(Cytokine 1) CK1
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IFN-γ, IL-2, TNF-β
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(Cytokine 2) CK2
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TGF-β, IL-4, IL-5, IL-6, IL-10, IL-13
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Cytotoxic T Lymphocyte Agent (CTL) Zones 2,3,1
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T CYTOTOXIC lymphocytes, cell-mediated, ADAPTIVE immunity
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CK1
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IFN-γ
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Natural Killer Cell Agent (NK) Zone 1
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Natural Killer Cells, cell-mediated immunity, kills stressed cells, INNATE immunity
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CK1
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IFN-γ
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B Cell Agent (B, B1, B2) Zones 2,3,1
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B Lymphocytes, ADAPTIVE, humoral immunity, makes antibodies
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(Antibody 1) Ab1
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Cytotoxic and neutralizing antibody
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(Antibody 2) Ab2
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Targeting and neutralizing antibody
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Complement
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Bound antibody catalyzes complement product formation, C3a, C5a [70]
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Granulocyte Agent (Gran) Zones 3,1
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Neutrophils, Eosinophils and Basophils, INNATE immunity, releases enzymes and toxins by degranulation and produces reactive oxygen species
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(Degranulation product 1) G1
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Degranulation products, reactive oxygen products
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Portal Agent Zones 1,2,3
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Blood vessels, lymphatic ducts. The only agent representing a structure rather than a cell type.
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