The Basic Immune Simulator: An agent-based model to study the interactions between innate and adaptive immunity

Table 3 Initial conditions and agent types involved in the immune hyper-response

Initial conditions	Fraction of simulation runs with identical starting conditions that ended in the *immune hyper-response* due to the agent types given.
(Conditions in Figure 2)	T1	T2	B1	B2	CTL	Number of runs
10 DCs	0.07	0.93	0.07	0.29	0	14
20 DCs	0	0.89	0.22	0.22	0	9
30 DCs	0.38	0.75	0.25	0.25	0	8
40 DCs	0.57	0.57	0.43	0.29	0	7
50 DCs	0	1.0	0	0	0	1
60 DCs	0.93	0.29	0.93	0	0	14
70 DCs	0.89	0.26	0.89	0.05	0	19
80 DCs	1.0	0.25	1.0	0	0	4
90 DCs	1.0	0.12	0.75	0.12	0	8
100 DCs	1.0	0.18	1.0	0.09	0	11
No DC apoptosis
50 DCs	0.86	0.09	0.32	0.03	0.11	66
Exclusion of CTLs from the simulated immune response
20 DCs	0.17	0.83	0.25	0	0	12
50 DCs	0.83	0.33	0.83	0	0	6
80 DCs	0.86	0.57	0.86	0.14	0	7
Exclusion of NKs from the simulated immune response
20 DCs	0.09	0.91	0.09	0.36	0	22
50 DCs	0.50	0.67	0.46	0.29	0.04	24
80 DCs	0.79	0.38	0.69	0.14	0	29
Exclusion of MΦs from the simulated immune response
20 DCs	0.10	0.84	0.10	0.16	0	19
50 DCs	0.64	0.45	0.64	0.09	0	11
80 DCs	1.0	0	1.0	0	0	1
More DCs recruited at immune activation
20 DCs	0.50	0.22	0.28	0	0.02	40
50 DCs	0.68	0.25	0.54	0.04	0.11	28
80 DCs	0.87	0.17	0.74	0.09	0.13	23
Increased CTL proliferation at activation
20 DCs	0.10	0.30	0.10	0	0.70	10
50 DCs	0.26	0.17	0.35	0	0.87	23
80 DCs	0.50	0	0.50	0	1.0	4

For the simulation runs that ended in the immune hyper-response, the fraction of the runs in which the agents representing the lymphocytes in Zone 2 that proliferated excessively are given. The fractions do not add up to 1.0 for each row because more than one agent type may have proliferated excessively. The agent types were counted as contributing to the hyper-response if more than 900 agents were present in Zone 2 at the time when the simulation run terminated. The simulation was programmed to terminate when more than 30,000 agents were detected to be participating at a given time. There were multiple check points to count the number of agents participating.

ISSN: 1742-4682