Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift

Table 1 Steady-state metabolite levels corresponding to mRNA profiles

			FOLD CHANGE (normalized against 11 hr)
Abbreviation	Symbol	Value (mol%)	9 hr	11 hr	13 hr	15 hr	17 hr	19 hr	21 hr
KDHS	X ₁	0.005	0.98	1	0.78	1.01	1.27	0.80	1.55
DHS	X ₂	0.01	1.13	1	0.53	0.77	0.50	1.98	7.88
Dihydro-C	X ₃	0.036	1.65	1	0.76	2.07	1.24	0.95	4.28
DHS-P	X ₄	0.001	1.27	1	0.36	0.48	0.32	2.31	15.76
PHS	X ₅	0.05	0.89	1	0.43	0.54	0.34	3.00	4.73
PHS-P	X ₆	0.005	0.99	1	0.24	0.29	0.18	4.21	12.96
Phyto-C	X ₇	0.052	0.86	1	0.51	0.51	0.55	0.33	1.02
IPC-g	X ₈	0.102	1.93	1	0.06	0.61	0.80	0.003	3.71
CDP-DAG	X ₉	5.4	1.18	1	0.44	0.72	0.95	0.76	3.13
PS	X ₁₀	8.4	0.77	1	1.22	2.79	3.37	4.15	8.14
PA	X ₁₁	3	1.06	1	0.82	1.51	2.11	2.46	5.11
Pal-CoA	X ₁₂	0.01 ^(*)	0.97	1	0.96	1.17	1.14	0.95	1.29
Serine	X ₁₃	2600 ^(*)	1	1	1	1	1	1	1
DAG, X14	X ₁₄	0.1	1.25	1	0.97	1.18	1.80	1.83	3.94
PI, X15	X ₁₅	16.7	1.03	1	0.57	0.78	1.14	0.36	1.74
Inositol	X ₁₆	24.1 ^(*)	1	1	1	1	1	1	1
CDP-Eth	X ₁₇	22	0.55	1	0.03	0.04	0.01	3.20	15.25
MIPC-g	X ₁₈	0.14	1.56	1	0.37	1.25	1.17	0.07	2.02
M(IP)2C-g	X ₁₉	0.0085	1.47	1	0.25	0.77	1.43	0.05	3.31
IPC-m	X ₂₀	0.918	1.93	1	0.06	0.61	0.80	0.003	3.71
MIPC-m	X ₂₁	1.26	1.56	1	0.37	1.25	1.17	0.07	2.02
M(IP)2C-m	X ₂₂	0.0765	1.47	1	0.25	0.77	1.43	0.05	3.31
C26-CoA	X ₂₃	0.5	0.79	1	4.33	1.97	4.21	0.47	0.06
Mal-CoA	X ₂₄	183 ^(*)	1.04	1	0.35	0.46	0.31	1.20	11.60
Ac-CoA	X ₂₅	870 ^(*)	1	1	1	1	1	1	1
Total IPC	X₈ + X₂₀	1.02	1.93	1	0.06	0.61	0.80	0.003	3.71
Total MIPC	X₁₈ + X₂₁	1.4	1.56	1	0.37	1.25	1.17	0.07	2.02
Total MIP₂C	X₁₉ + X₂₂	0.085	1.47	1	0.25	0.77	1.43	0.05	3.31
Total_Ceramide	X₃ + X₇	0.088	1.18	1	0.61	1.15	0.83	0.59	2.35

(*) μM. Steady-state metabolite levels corresponding to microarray time course data during the diauxic shift (from DeRisi et al. [1]). Each case is represented as fold change of the value presented in Alvarez-Vasquez et al. [9]

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