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Table 2 Specific enzyme activities

From: Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift

 

Abbreviation

 

Activity (U/mg)

Ref.

GLYCEROLIPID BLOCK:

    

Phosphatidylinositol Synthase

PI Synthase

X 26

0.00266

[57]

Phosphatidylserine Synthase

PS Synthase

X 38

0.00332

[57]

Phosphatidate Phosphatase

PA-Ppase

X 39

0.0024

[58]

CDP-Diacylglycerol Synthase

CDP-DAG Synthase

X 40

0.00061

[59]

DG-Choline Phosphotransferase

ChoPT

X 42

0.00066

[60]

Phosphoinositide Kinase

PI Kinase

X 44

0.00172

[61]

Diacylglycerol-Ethanolamine Phosphotransferase

EthPT

X 45

0.001

[60]

Inositol-1-P Synthase

I-1-P Synth

X 46

0.000833

[62]

Glycerol-3-Phosphate Acyltransferase

G3P Acyltranferase

X 49

0.00394

[63]

Phosphatidylserine Decarboxilase

PS Decarboxylase

X 56

0.00001066

[64]

Phospholipase B

Phospholipase B

X 68

0.0005

δ

SPHINGOLIPID BLOCK:

    

3-Ketodihydrosphingosine Reductase

KDHS Reductase

X 27

0.000262

[65]

Dihydroceramide Alkaline Ceramidase

Dihydro-Cdase

X 29

0.0000054

[66]

Inositol Phosphorylceramide Synthase

IPC Synthase

X 33

0.00033

[67]

Ceramide Synthase

Cer Synthase

X 34

0.0000165

[68]

Mannosyl Inositol Phosphoceramide Synthase

MIPC Synthase

X 35

0.000165

[8, 69]

Sphingoid Base Kinase

Sphingoid Base Kinase

X 36

0.000004

[43]

Sphingoid-1-phosphate Phosphatase

SB-Ppase

X 41

0.0008

[70]

GUP1p

GUP1p

X 43

0.0001

δ

Sphingosine-Phosphate Lyase

Lyase

X 50

0.0000367

[71]

IPCase, Phyto-C formation

IPCase

X 51

0.00015

[72]

Phytoceramide Ceramidase

Phyto-Cdase

X 53

0.0000198

[66]

4-Hydroxylase

Hydroxylase

X 54

0.00017

 

Mannosyldiinositol Phosphorylceramide Synthase

M(IP)2C Synthase

X 55

0.0000825

[8, 69]

Serine Palmitoyltransferase

SPT

X 57

0.000106

[65]

Very Long Chain Fatty Acid Synthase

ELO1p

X 59

0.0006

[73]

IPCase, Dihydro-C formation

IPCase

X 64

0.00015

[72]

PRECURSOR BLOCK:

    

Transport/Palmitoyl CoA Synthase

Transp./Palmitoyl CoA Synthase

X30

0.0508

[74]

Phosphoserine-Phosphatase

P-Serine-PPase

X 31

0.0013

[75]

Serine Hydroxymethyl Transferase

SHMT

X 32

0.0045

[76]

Acyl-CoA-Binding Protein

ACBP

X 48

20 (*)

[77]

Fatty Acid Synthetase

FAS

X 52

0.0089

[78]

Acetyl-Coenzyme A Carboxylase

ACCp

X 60

0.022

[79]

Acetyl-Coenzyme A Synthetase

ACSp

X 63

0.73

[80]

Serine Transport

Serine Transport

X 65

0.0193224

[81, 82]

  1. (*) μM. (δ) Estimated. Specific enzyme activities during the exponential growth phase; from Alvarez-Vasquez et al. [9]. The enzymes were categorized into glycerolipid, sphingolipid, and precursor blocks.
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Theoretical Biology and Medical Modelling

ISSN: 1742-4682