Changing measure of FSC over time. The measured value ζ of a biosequence S can change over time with mutation events. Changes in FSC between ti and tj may indicate changes in the amount of order or randomness of the sequence. If OSC and RSC are represented as a continuum (as shown at left), a functional sequence at time t will have a FSC and time value as well as OSC/RSC values. If, as shown at right, OSC, RSC, FSC and time are represented as a 4-dimensional space, then a functional sequence S(ti) will have discrete FSC, OSC, RSC and time values.