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Table 1 FSC of Selected Proteins

From: Measuring the functional sequence complexity of proteins

  length (aa) Number of Sequences Null State (Bits) FSC (Fits) FSC Density Fits/aa
Ankyrin 33 1,171 143 46 1.4
HTH 8 41 1,610 177 76 1.9
HTH 7 45 503 194 83 1.8
HTH 5 47 1,317 203 80 1.7
HTH 11 53 663 229 80 1.5
HTH 3 55 3,319 238 80 1.5
Insulin 65 419 281 156 2.4
Ubiquitin 65 2,442 281 174 2.7
Kringle domain 75 601 324 173 2.3
Phage Integr N-dom 80 785 346 123 1.5
VPR 82 2,372 359 308 3.7
RVP 95 51 411 172 1.8
Acyl-Coa dh N-dom 103 1,684 445 174 1.7
MMR HSR1 119 792 514 179 1.5
Ribosomal S12 121 603 523 359 3.0
FtsH 133 456 575 216 1.6
Ribosomal S7 149 535 644 359 2.4
P53 DNA domain 157 156 679 525 3.3
Vif 190 1,982 821 675 3.6
SRP54 196 835 847 445 2.3
Ribosomal S2 197 605 851 462 2.4
Viral helicase1 229 904 990 335 1.5
Beta-lactamase 239 1,785 1,033 336 1.4
RecA 240 1,553 1,037 832 3.5
Bac luciferase 272 1,900 1,176 357 1.3
tRNA-synt 1b 280 865 1,210 438 1.6
SecY 342 469 1,478 688 2.0
EPSP Synthase 372 1,001 1,608 688 1.9
FTHFS 390 658 1,686 1,144 2.9
DctM 407 682 1,759 724 1.8
Corona S2 445 836 1,923 1,285 2.9
Flu PB2 608 1,692 2,628 2,416 4.0
Usher 724 316 3,129 1,296 1.8
Paramyx RNA Pol 887 389 3,834 1,886 2.1
ACR Tran 949 1,141 4,102 1,650 1.7
Random sequences 1000 500 4,321 0 0
50-mer polyadenosine 50 1 0 0 0
  1. Results for 35 protein families Shown above are the 35 protein families analyzed, their sequence length (column 1), the number of sequences analyzed for each family (column 2), the Shannon uncertainty of the Null State Hø (Eqn. 4) for each protein (column 3), the FSC value ζ in Fits for each protein (column 4), and the average Fit value/site (FSC/length, column 5). For comparison, the results for a set of uniformly random amino acid sequences (RSC) are shown in the second from last row, and a highly ordered, 50-mer polyadenosine sequence (OSC) in the last row. All values, except for the OSC example, which was calculated from the constrained ground state required to produce OSC, were computed from the null state. The Fit values obtained can be discussed as the measure of the change in functional uncertainty required to specify any functional sequence that falls into the given family being analyzed.