Astrocytic hypoxia. Effect of oxygen deprivation of astrocytes on metabolic fluxes calculated by MOMA approach. All the x-axes represent the oxygen flux available to astrocytic cells. It is changed from anoxic level (no oxygen uptake) to the basal level (0.53 μmole/g/min). (no lactate release from neurons). The title of each sub-figure includes the reaction number of the plotted flux, as given in Additional File 1.