Skip to main content
Figure 7 | Theoretical Biology and Medical Modelling

Figure 7

From: A unified framework of immunological and epidemiological dynamics for the spread of viral infections in a simple network-based population

Figure 7

Viral dynamics for re-infection to antigen when it is eliminated compared to when it persists. Antigen was re-introduced to the whole population, at t = 1000, 3000, 6000, and 9000 days (yellow and blue lines), or at a single time step (t = 9000 days) (black and red lines) under the assumption of antigenic elimination and antigenic persistence, respectively. Here, ω i = 0.1, and a v ext = 0.015 was used in antigenic elimination simulations. (A) With the exception of antigenic persistence (red and blue lines), re-infection for the population at different intervals produces qualitatively different behaviour than antigenic elimination (yellow and black lines). However, the asymptotic accumulated viral load in the population is similar, regardless of whether or not antigen persists or is eliminated. (B) These qualitative differences are also observable for the mean viral load in the population. Assuming either scenario one or two, a small positive growth in the mean viral load following re-infection at t = 1000, 3000, 6000 days (yellow line), and at t = 9000 days (black and red lines) occurs.

Back to article page