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Table 2 Kinetic parameters. Concentrations and the Michaelis-Menten constants (K4, K8, and K11-K19) are given in [nM]. First- and second-order rate constants are given in [s-1] and [nM-1·s-1], respectively. V4, V8, and V11-V19 are expressed in [nM·s-1].

From: Simulating non-small cell lung cancer with a multiscale agent-based model

Reaction number

Equation

Kinetic parameter

 

Reference

v1

k1·X1·X2 - k-1·X3

k1 = 0.003

k-1 = 0.06

[11]

v2

k2·X3·X3 - k-2·X4

k2 = 0.01

k-2 = 0.1

[11]

v3

k3·X4 - k-3·X5

k3 = 1

k-3 = 0.01

[11]

v4

V4·X5/(K4 + X5)

V4 = 450

K4 = 50

[11]

v5

k5·X5·X6 - k-5·X7

k5 = 0.06

k-5 = 0.2

[11]

v6

k6·X7 - k-6·X8

k6 = 1

k-6 = 0.05

[11]

v7

k7·X8 - k-7·X5·X9

k7 = 0.3

k-7 = 0.006

[11]

v8

V8·X9/(K8 + X9)

V8 = 1

K8 = 100

[11]

v9

k9·X9 - k-9·X10

k9 = 1

k-9 = 0.03

[11]

v10

k10·X9·X11 - k-10·X12

k10 = 0.214

k-10 = 5.25

Estimate

v11

V11·X12·X13/(K11 + X13)

V11 = 4

K11 = 64

[39]

v12

V12·X14·X15/[K12·(1 + X16/K14) + X15]

V12 = 3.5

K12 = 317

[14]

v13

V13·X16/[K13·(1 + X17/K15) + X16]

V13 = 0.058

K13 = 2200

[12]

v14

V14·X14·X16/[K14·(1 + X15/K12) + X16]

V14 = 2.9

K14 = 317

[12]

v15

V15·X17/[K15·(1 + X16/K13) + X17]

V15 = 0.058

K15 = 60

[12]

v16

V16·X17·X18/[K16·(1 + X19/K18) + X18]

V16 = 9.5

K16 = 1.46 × 105

[12]

v17

V17·X19/[K17·(1 + X20/K19) + X19]

V17 = 0.3

K17 = 160

[12]

v18

V18·X17·X19/[K18·(1 + X18/K16) + X19]

V18 = 16

K18 = 1.46 × 105

[12]

v19

V19·X20/[K19·(1 + X19/K17) + X20]

V19 = 0.27

K19 = 60

[12]