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Figure 1 | Theoretical Biology and Medical Modelling

Figure 1

From: Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability

Figure 1

F is an external stress that triggers the hypothalamus to release CRH (C) that signals to the pituitary to release ACTH (A) stimulating the synthesis and release of cortisol (O) from the adrenals. Release of cortisol negatively regulates CRH and ACTH after binding to the glucocorticoid receptor (R) in the pituitary. Here, GR and cortisol regulate further GR synthesis.

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