Figure 10

Screenshots of Bilayer Gut ABM. Bilayer configuration of the gut ABM, following the structure for "hollow" organs described in the text. Figure 10a is the view of bilayer from endothelial surface. Red cubes represent endothelial cell agents, with spherical inflammatory cell agents seen just below. Inflammatory cell agents move in the plane immediately below the endothelial surface, and these interaction rules are derived from the Innate Immune response ABM from Ref. [6]. Figure 10b is the view of bilayer from epithelial surface. Pink cubes represent epithelial cell agent, governed by rules transferred from the EBABM. Impairment of TJ protein metabolism is shown by darkening of the color of the epithelial cell agent, with the epithelial cell agents eventually turning black and changing their shape to a "cone" when TJs have failed (see Figures 11, 14–16).