Figure 14

Simulated "Pneumonia" with effect on Gut Barrier Dysfunction. This panel shows a representative run of the Gut-Lung Axis ABM with "pneumonia" as the initial perturbation. Letter A demonstrates the localized injury to the pulmonary bilayer, Letter B demonstrates areas of the gut epithelial layer that are starting to have impaired TJ protein metabolism due to gut ischemia from decreased systemic oxygenation arising from pulmonary leak.