Figure 16

Effect of Simulated Supplementary Oxygen on dynamics of simulated Pneumonia. Figure 16a demonstrates the dynamics of pulmonary Cytoplasm and Cellwall occludin in a representative run with an initial "%Isch" = 15, and the addition of simulated organ support in the form of "Supplementary Oxygen" at 50%. The effect of "Supplementary Oxygen" is additive to the level of "oxy" generated by the lung ABM and distributed to the endothelial surface. The initial drop of the pulmonary Occludins is consistent with inflammatory effects of post-ischemic mesenteric lymph. The effect of the "Supplementary Oxygen" is to blunt the effect of the resulting pulmonary edema, and it keeps the "oxy" level above the threshold ischemic level for activation of the generalized endothelial cell agent population. As a result the endothelial surface if maintained through the period of most intense inflammation, and allows the epithelial cells to begin recovery of their TJs (see Letter A in Figure 16a). The stabilization and initiation of recovery of pulmonary epithelial TJs at 72 hours is consistent with the clinical time course of adult respiratory distress syndrome due to an episode of shock. Figure 16b is a concurrent screenshot of the representative run. Letter A demonstrates the intact endothelial agent layer due to "Supplementary Oxygen" support (compare with Figure 15c, Letter A). Letter B demonstrates the recovering pulmonary epithelial cell agents. Letter C demonstrates intact and recovering gut epithelial.