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Figure 5 | Theoretical Biology and Medical Modelling

Figure 5

From: Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation

Figure 5

Simulated Nitrogen Oxide (NO) Production and response to NO Scavenger. Calibration data is seen in the black bars (= Cytomix) and the beige bars (= NO) with respect to simulation rules for NO production. The NO data match the levels of exogenous NO added in the experiments from [26]) in order to establish baseline responses of the epi-cell agent's TJ protein synthesis/localization algorithms and link them to the permeability data seen in the corresponding bars in Figure 5. The Cytomix bars in this Figure 4 are used to calibrate the iNOS-NO production algorithms within the epi-cell agents. The middle data set (grey bars = Cytomix + NO scavenger) show the effect of exogenous NO reduction/elimination on the generated levels of NO in the face of Cytomix. This graph can be compared to the upper panel of Figure 1 in Ref [26].

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682