Skip to main content
Figure 1 | Theoretical Biology and Medical Modelling

Figure 1

From: Heterogeneity in multistage carcinogenesis and mixture modeling

Figure 1

The multistage carcinogenesis model. N0 denotes the number of normal stem cells. To get initiated, a normal cell accumulates n consecutive mutations, where ν denotes the mutation rate per cell per year for the gene in question. The number of cells having k mutations is noted I k , 1 ≤ kn. The fully initiated cells, I n , expand according to a birth-and-death process. These cells give rise to tumor cells T if a further event happens, and μ/(μ + β) can be interpreted as the probability of such a malignant transformation during a cell division.

Back to article page