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Table 1 Accumulated Affinity between Codons

From: Correlation between nucleotide composition and folding energy of coding sequences with special attention to wobble bases

CF

 

1

1

2

2

2

2

2

2

2

2

2

3

3

4

4

4

4

4

6

6

6

 

AA

Met

Trp

Lys

Glu

Phe

Asn

Gln

His

Tyr

Asp

Cys

End

Ile

Pro

Gly

Thr

Ala

Val

Leu

Arg

Ser

1

Met

2.8

2.6

0.0

0.0

3.2

3.2

3.3

3.6

3.1

2.9

3.1

3.2

3.7

3.4

2.8

3.4

3.2

3.6

3.7

3.4

3.9

1

Trp

2.6

1.0

0.0

0.0

3.1

3.2

3.3

3.7

3.6

3.2

3.4

2.9

3.5

3.9

3.0

3.9

3.8

3.0

4.0

3.7

3.7

2

Lys

0.0

0.0

0.0

0.0

3.8

0.0

0.0

3.1

3.3

0.0

3.3

0.0

3.4

3.1

0.0

2.9

2.9

3.4

3.9

3.1

3.9

2

Glu

0.0

0.0

0.0

0.0

3.9

0.0

0.0

3.6

3.4

0.0

3.4

0.0

3.5

3.9

0.0

3.5

3.5

3.5

4.2

3.6

4.2

2

Phe

3.2

3.1

3.8

3.9

0.0

3.4

3.3

0.0

0.0

3.5

0.0

3.6

3.1

0.0

4.0

3.5

3.3

3.3

0.0

4.0

3.2

2

Asn

3.2

3.2

0.0

0.0

3.4

2.9

0.0

2.8

3.5

3.2

3.7

3.6

3.6

0.0

3.2

2.9

3.0

3.9

4.0

3.2

3.8

2

Gln

3.3

3.3

0.0

0.0

3.3

0.0

3.2

0.0

3.2

3.3

4.0

3.6

2.8

3.3

3.5

2.9

3.9

4.0

4.1

3.7

3.9

2

His

3.6

3.7

3.1

3.6

0.0

2.8

0.0

2.7

2.7

3.7

3.6

3.8

3.2

0.0

4.0

3.1

3.6

4.0

3.7

3.9

3.7

2

Tyr

3.1

3.6

3.3

3.4

0.0

3.5

3.2

2.7

3.5

3.2

3.2

3.9

3.7

0.0

3.9

3.4

3.3

4.0

3.7

3.8

4.0

2

Asp

2.9

3.2

0.0

0.0

3.5

3.2

3.3

3.7

3.2

3.2

3.5

3.4

3.8

3.7

3.4

3.5

3.5

4.0

4.0

3.9

4.2

2

Cys

3.1

3.4

3.3

3.4

0.0

3.7

4.0

3.6

3.2

3.5

3.5

3.7

3.6

3.6

4.0

3.9

4.2

3.8

3.7

4.1

3.9

3

End

3.2

2.9

0.0

0.0

3.6

3.6

3.6

3.8

3.9

3.4

3.7

3.8

4.0

3.7

3.3

3.9

3.8

3.9

4.3

3.8

4.2

3

Ile

3.7

3.5

3.4

3.5

3.1

3.6

2.8

3.2

3.7

3.8

3.6

4.0

3.9

0.0

3.8

3.6

3.2

4.0

4.0

3.8

4.0

4

Pro

3.4

3.9

3.1

3.9

0.0

0.0

3.3

0.0

0.0

3.7

3.6

3.7

0.0

3.2

4.5

3.3

4.1

4.2

3.6

4.3

3.9

4

Gly

2.8

3.0

0.0

0.0

4.0

3.2

3.5

4.0

3.9

3.4

4.0

3.3

3.8

4.5

3.5

4.2

4.3

4.0

4.5

4.2

4.4

4

Thr

3.4

3.9

2.9

3.5

3.5

2.9

2.9

3.7

3.4

3.5

3.9

3.9

3.6

3.3

4.2

3.2

3.9

4.4

4.2

4.2

4.3

4

Ala

3.2

3.8

2.9

3.5

3.3

3.0

3.9

3.6

3.3

3.5

4.2

3.8

3.2

4.1

4.3

3.9

4.5

4.4

4.3

4.4

4.3

4

Val

3.6

3.0

3.4

3.5

3.3

3.9

4.0

4.0

4.0

4.0

3.8

3.9

4.0

4.2

4.0

4.4

4.4

3.6

4.3

4.4

4.1

6

Leu

3.7

4.0

3.9

4.2

0.0

4.0

4.1

3.7

3.7

4.0

3.7

4.3

4.0

3.6

4.5

4.2

4.3

4.3

4.0

4.5

4.3

6

Arg

3.4

3.7

3.1

3.6

4.0

3.2

3.7

3.9

3.8

3.9

4.1

3.8

3.8

4.3

4.2

4.2

4.4

4.4

4.5

4.5

4.6

6

Ser

4.0

3.8

3.9

4.2

3.2

3.7

3.9

3.5

3.8

4.2

4.0

4.2

3.8

3.8

4.5

4.2

4.4

4.2

4.3

4.6

4.1

  1. Each value is the accumulated affinity (dG) between synonymous codons corresponding to the indicated amino acids (log-kcal/mol);
  2. CF: codon frequency/number of synonymous codons/amino acid. Highest (>4) and lowest (<3) values are indicated.