The figure shows a simplified chemical structure of PGLA. X represents lactic acid while y represents glycolic acid. Notice the availability of the hydroxyl (-OH) and free hydrogen (+H) ions at lactic and glycolic extremities of the PLGA molecule respectively. This possibly accounts for diversity of PLGA solvent solubility. PLGA may thus effectively be used to complex both EcoRII and nonoxynol-9 by a two step emulsion of EcoRII first in PLGA; followed by a final emersion in nonoxynol-9.