Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling

Table 1 Pharmacokinetic parameters of various compounds used as inputs for each WBPBPK model simulation

Compound	Rat							Human				References
	CL_tot (mL/h/kg)	CL_h (mL/h/kg)	CL_r (mL/h/kg)	CL_s (mL/h/kg)	T_1/2 (h)	R_B^a	f_B	CL_tot (mL/h/kg)	T_1/2 (h)	R_B^a	f_B
Tolbutamide	109	109	0	0	1.8	0.75	0.36	24.0	7.0	0.75	0.12	11–13
Diclofenac	1809	1176	633	0	0.14	0.55	0.009	447	1.2	0.55	0.009	12, 14–19
Midazolam	3024	1542	269	1213	0.53	1	0.066	473	2.8	0.80	0.043	12, 20–22
Diazepam	2492	2343	149	0	1.1	1.04	0.13	40.4	32.8	1.04	0.03	12, 23, 24
Phenytoin	1806	1246	181	379	0.37	0.99	0.23	187	13.2	0.61	0.20	11, 12, 14, 25, 26
Imipramine	2544	1649	895	0	3.5	1.67	0.01	424	16.5	1.67	0.14	12, 27–30
Lidocaine	4252	1276	2764	213	0.57	1.27	0.30	938	2.1	0.80	0.81	12, 31–35
Gatifloxacin	1101	341	574	186	1.8	1.07	0.68	252	6.5	1.07	0.75	36
Grepafloxacin	1079	917	151	11	3.4	1.34	0.44	245	11.6	1.1	0.45	37–39
Gemifloxacin	1300	163	599	432	1.6	1	0.57	500	7.0	1.2	0.30	40, 41
Pazufloxacin	970	90	721	159	0.88	1	0.74	384	1.8	1	0.77	38, 42–45
Enoxacin	1794	57	940	797	1.8	0.91	0.71	527	6.0	0.91	0.57	38, 46–48
Fleroxacin	285	57	195	34	2.6	1.29	0.40	120	9.5	1	0.77	36, 38, 49
Lomefloxacin	1243	973	270	0	4.0	1	0.69	252	7.1	1	0.79	50, 51

^aR_B (blood-plasma concentration ratio) assumed to be 1 when there were no data in the literature.

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