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Table 1 Pharmacokinetic parameters of various compounds used as inputs for each WBPBPK model simulation

From: Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling

Compound Rat Human References
  CLtot
(mL/h/kg)
CLh
(mL/h/kg)
CLr
(mL/h/kg)
CLs
(mL/h/kg)
T1/2
(h)
RBa fB CLtot
(mL/h/kg)
T1/2
(h)
RBa fB  
Tolbutamide 109 109 0 0 1.8 0.75 0.36 24.0 7.0 0.75 0.12 11–13
Diclofenac 1809 1176 633 0 0.14 0.55 0.009 447 1.2 0.55 0.009 12, 14–19
Midazolam 3024 1542 269 1213 0.53 1 0.066 473 2.8 0.80 0.043 12, 20–22
Diazepam 2492 2343 149 0 1.1 1.04 0.13 40.4 32.8 1.04 0.03 12, 23, 24
Phenytoin 1806 1246 181 379 0.37 0.99 0.23 187 13.2 0.61 0.20 11, 12, 14, 25, 26
Imipramine 2544 1649 895 0 3.5 1.67 0.01 424 16.5 1.67 0.14 12, 27–30
Lidocaine 4252 1276 2764 213 0.57 1.27 0.30 938 2.1 0.80 0.81 12, 31–35
Gatifloxacin 1101 341 574 186 1.8 1.07 0.68 252 6.5 1.07 0.75 36
Grepafloxacin 1079 917 151 11 3.4 1.34 0.44 245 11.6 1.1 0.45 37–39
Gemifloxacin 1300 163 599 432 1.6 1 0.57 500 7.0 1.2 0.30 40, 41
Pazufloxacin 970 90 721 159 0.88 1 0.74 384 1.8 1 0.77 38, 42–45
Enoxacin 1794 57 940 797 1.8 0.91 0.71 527 6.0 0.91 0.57 38, 46–48
Fleroxacin 285 57 195 34 2.6 1.29 0.40 120 9.5 1 0.77 36, 38, 49
Lomefloxacin 1243 973 270 0 4.0 1 0.69 252 7.1 1 0.79 50, 51
  1. aRB (blood-plasma concentration ratio) assumed to be 1 when there were no data in the literature.