|
Parameter
|
Group
|
T1/2
|
CLtot
|
|---|
| | |
6 organs
|
8 organs
|
10 organs
|
6 organs
|
8 organs
|
10 organs
|
|---|
| | |
+
|
-
|
+
|
-
|
+
|
-
|
+
|
-
|
+
|
-
|
+
|
-
|
|---|
|
AFE
|
acidic
|
5.45
|
38.7
|
2.26
|
16.6
|
1.36
|
13.5
|
1.39
|
305
|
1.07
|
26.5
|
2.56
|
14.7
|
| |
neutral
|
3.58
|
36.6
|
2.97
|
2.12
|
1.64
|
2.25
|
4.01
|
68.5
|
1.47
|
14.8
|
1.38
|
10.8
|
| |
basic
|
4.13
|
36.8
|
1.85
|
7.48
|
1.76
|
6.28
|
1.34
|
24.4
|
1.62
|
5.64
|
1.10
|
4.37
|
| |
zwitterionic
|
2.80
|
14.4
|
1.41
|
5.10
|
1.36
|
3.85
|
1.40
|
33.3
|
1.48
|
7.40
|
1.63
|
5.67
|
|
AFE
|
Overall
|
3.35
|
23.2
|
1.75
|
5.78
|
1.48
|
4.74
|
1.63
|
47.4
|
1.47
|
9.24
|
1.56
|
6.74
|
|
within-2-fold (%)
| |
0
|
0
|
62
|
14
|
93
|
14
|
92
|
0
|
92
|
0
|
79
|
0
|
- +: WBPBPK model with SAC, -: WBPBPK model without SAC.
