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Table 3 AFE values and within-2-fold errors from the present study and previous studies

From: Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling

  Method n AFE Within-2-fold error (%)
    T1/2 CLtot T1/2 CLtot
Present work SAC-WBPBPK 14 1.5 1.6 93 79
  generic WBPBPK 197) 2.2 2.7 71 71
   19 or 268) 1.5 1.1 69 74
Previous work in silico 61) 18 N/A 2.8 N/A 50
  animal scale-up 191) 2.4 3.4 53 37
   1862) N/A 2.5 N/A 50
  1. N/A: not available.