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Table 3 AFE values and within-2-fold errors from the present study and previous studies

From: Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling

 

Method

n

AFE

Within-2-fold error (%)

   

T1/2

CLtot

T1/2

CLtot

Present work

SAC-WBPBPK

14

1.5

1.6

93

79

 

generic WBPBPK

197)

2.2

2.7

71

71

  

19 or 268)

1.5

1.1

69

74

Previous work

in silico 61)

18

N/A

2.8

N/A

50

 

animal scale-up

191)

2.4

3.4

53

37

  

1862)

N/A

2.5

N/A

50

  1. N/A: not available.
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Theoretical Biology and Medical Modelling

ISSN: 1742-4682