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Figure 1 | Theoretical Biology and Medical Modelling

Figure 1

From: Transient antiretroviral therapy selecting for common HIV-1 mutations substantially accelerates the appearance of rare mutations

Figure 1

Growth of a rare mutant in the deterministic model. Growth of a rare mutant strain (ie. with no waiting time) in the deterministic model. The initial value of the rare mutant (P3) is zero whereas viral strains: wild-type (P1) and common mutant (P2) begin their dynamics from the steady state. The rare mutant is immediately produced continuously and grows according to its fitness advantage. The time required to attain one cell infected by this rare mutant is of the order of weeks. In these simulations, the differential fitness parameters are given by (k3, k2, k1) = (2k1, 0.9k1, k1) where k1 = 2 × 10-8; that is, the environment favours the rare mutant to outgrow existing viral variants.

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