Figure 4

Transient increase of common mutations. Relative frequency of K103N during and after 7 days of idealized treatment. Short-course highly selective therapy results in dramatic increases in pre-existing resistant viral variants. Withdrawal of therapy results in a slow decline of the subpopulation. We assume that 10% of infected cells become long-lived infected cells and are activated after 2 weeks i.e. we set F = 0.90 and a = 1/14.