Steady-state profiles of DISC, tBid-Bax
, and apoptosome. Steady-state concentrations of DISC, tBid-Bax2, and apoptosome, used for modularization of the DISC, MAC, and apoptosome modules, respectively. (a) The steady-state DISC concentration [DISC]ss as a function of the initial death ligand ([FasL]0) and receptor ([FasR]0) concentrations. (b) The steady-state tBid-Bax2 concentration [tBid-Bax2]ss as a function of the initial Bax ([Bax]0) and tBid ([tBid]0) concentrations. (c) The steady-state apoptosome concentration [Apop]ss as a function of the initial Apaf-1 ([Apaf]0) and cytochrome c ([Cytc]0) concentrations.