Figure 7
From: Construction and analysis of a modular model of caspase activation in apoptosis
Type II prediction time course. Time course of caspase-3 activation ([Casp3*]) for the type II apoptosis cell prediction parameters (k-4 = k-6 = 10-3 s-1, [XIAP]0 = 200 nM, [FasR]0 = 1 nM) induced by [FasL]0 = 2 nM. The solid line gives the time course of the full model, while the dashed line gives the time course with k7 = 0 (i.e., no Bid truncation, hence no extrinsic-intrinsic coupling). Note the significant delay in caspase activation.