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Table 2 Reactions for the model equations

From: Construction and analysis of a modular model of caspase activation in apoptosis

Number Reaction Forward rate (nM-1 s-1) Reverse rate (s-1)
DISC (FasL, FasR) → DISC f DISC  
1 DISC + Casp8 → DISC + Casp8* 10-4 (k2)  
2 Casp3* + Casp8 → Casp3* + Casp8* 10-4 [65]  
3 Casp8* + Casp3 → Casp8* + Casp3* 5.8 × 10-4 [65]  
4 Casp3* + XIAP Casp3*-XIAP 3 × 10-3 [65] 0.035 [65]
5 Casp3* + XIAP → Casp3* 3 × 10-3 [65]  
6 Casp8* + BAR Casp8*-BAR 5 × 10-3 [65] 0.035 [65]
7 Casp8* + Bid → Casp8* + tBid 5 × 10-4 (est. [70, 71])  
tBid-Bax2 (tBid, Bax) → tBid-Bax2 f tBid-Bax 2 MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaemOzay2aaSbaaSqaaiabbsha0jabbkeacjabbMgaPjabbsgaKjabb2caTiabbkeacjabbggaHjabbIha4naaBaaameaacqaIYaGmaeqaaaWcbeaaaaa@384E@  
8 tBid-Bax2 + Cytc → tBid-Bax2 + Cytc* 10-3 [70, 71]  
9 tBid-Bax2 + Smac → tBid-Bax2 + Smac* 10-3 [70, 71]  
10 Smac* + XIAP Smac*-XIAP 7 × 10-3 [70, 71] 2.21 × 10-3 [70, 71]
Apop (Cytc*; Apaf) → Apop f Apop  
11 Apop + Casp9 → Apop + Casp9* 2 × 10-4 (est. [66])  
12 Casp3* + Casp9 → Casp3* + Casp9* 2 × 10-4 [66]  
13 Casp9* + Casp3 → Casp9* + Casp3* 5 × 10-5 [66]  
14 Casp9* + XIAP Casp9*-XIAP 1.06 × 10-4 [70, 71] 10-3 [70, 71]
  1. Each reaction described highlights whether the reaction is a forward or reversible reaction by the arrows. The rates are provided from previous work. Reaction are illustrated in Figure 1.