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Table 5 Summary of all rates and parameters for the system

From: Construction and analysis of a modular model of caspase activation in apoptosis

  Forward rate   Reverse rate   Synthesis rate   Degradation rate   Parameter
1 k 1 15 k -4 19 α Casp8 27 μ DISC 48 [FasL]0
2 K 2 16 k -6 20 α Casp3 28 μ Casp8 49 [FasR]0
3 k 3 17 k -10 21 α XIAP 29 μ Casp8* 50 K DISC
4 k 4 18 k -14 22 α BAR 30 μ Casp3 51 [Bax]0
5 k 5    23 α Bid 31 μ Casp3* 52 K tBid-Bax 2 MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaem4saS0aaSbaaSqaaiabbsha0jabbkeacjabbMgaPjabbsgaKjabb2caTiabbkeacjabbggaHjabbIha4naaBaaameaacqaIYaGmaeqaaaWcbeaaaaa@3818@
6 k 6    24 α Cytc 32 μ XIAP 53 [Apaf]0
7 k 7    25 α Smac 33 μ Casp3*-XIAP 54 λ Apop
8 k 8    26 α Casp9 34 μ BAR   
9 K 9      35 μ Casp8*-BAR   
10 k 10      36 μ Bid   
11 k 11      37 μ tBid   
12 k 12      38 μ tBid-Bax 2 MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaGaeqiVd02aaSbaaSqaaiabbsha0jabbkeacjabbMgaPjabbsgaKjabb2caTiabbkeacjabbggaHjabbIha4naaBaaameaacqaIYaGmaeqaaaWcbeaaaaa@38AF@   
13 k 13      39 μ Cytc   
14 K 14      40 μ Cytc*   
       41 μ Smac   
       42 μ Smac*   
       43 μ Smac*-XIAP   
       44 μ Apop   
       45 μ Casp9   
       46 μ Casp9*   
       47 μ Casp9*-XIAP   
  1. The counter on the left hand columns totals the 54 model rates and parameters for the full system. Each subscript for k, α and μ corresponds to its reaction number. The final column are the parameters used in the abstraction of oligomerization kinetics for the three modules.