Construction and analysis of a modular model of caspase activation in apoptosis

Table 5 Summary of all rates and parameters for the system

	Forward rate		Reverse rate		Synthesis rate		Degradation rate		Parameter
1	k ₁	15	k _-4	19	α _Casp8	27	μ _DISC	48	[FasL]₀
2	K ₂	16	k _-6	20	α _Casp3	28	μ _Casp8	49	[FasR]₀
3	k ₃	17	k _-10	21	α _XIAP	29	μ _Casp8*	50	K _DISC
4	k ₄	18	k _-14	22	α _BAR	30	μ _Casp3	51	[Bax]₀
5	k ₅			23	α _Bid	31	μ _Casp3*	52	$K_{{tBid-Bax}_{2}}$
6	k ₆			24	α _Cytc	32	μ _XIAP	53	[Apaf]₀
7	k ₇			25	α _Smac	33	μ _Casp3*-XIAP	54	λ _Apop
8	k ₈			26	α _Casp9	34	μ _BAR
9	K ₉					35	μ _Casp8*-BAR
10	k ₁₀					36	μ _Bid
11	k ₁₁					37	μ _tBid
12	k ₁₂					38	$μ_{{tBid-Bax}_{2}}$
13	k ₁₃					39	μ _Cytc
14	K ₁₄					40	μ _Cytc*
						41	μ _Smac
						42	μ _Smac*
						43	μ _Smac*-XIAP
						44	μ _Apop
						45	μ _Casp9
						46	μ _Casp9*
						47	μ _Casp9*-XIAP

The counter on the left hand columns totals the 54 model rates and parameters for the full system. Each subscript for k, α and μ corresponds to its reaction number. The final column are the parameters used in the abstraction of oligomerization kinetics for the three modules.

ISSN: 1742-4682