substrate | clinical change 1 | clinical change 2 | H2O2 × 5 | H2O2 × 5 adenosine up |
|---|
Hcy | -5 | -9 | -19 | -39 |
Met | -26 | -39 | -20 | -26 |
bCys | -20 | -19 | -9 | -9 |
bGSH | -32 | -46 | -35 | -34 |
SAM | -10 | -22 | -61 | -22 |
SAH | 24 | 49 | -54 | 24 |
bGSH/bGSSG | -48 | -66 | -88 | -88 |
5mTHF | -- | -- | 154 | 144 |
vDNMT | -- | -- | -6 | -10 |
- *Clinical data in columns 1 and 2 are average changes in blood levels of metabolites in autistic children compared to control patients [14, 15]. Columns 3 and 4 show % changes in model values. In columns 3 and 4 bCys, bGSH and bGSSG indicate model blood concentrations, and the other metabolites are intracellular. vDNMT is the velocity of the DNA methylation reaction (μM/hr). Column 3 shows the effect of severe oxidative stress that is a factor of 5 higher than normal. Column 4 shows the effect of adding increased adenosine concentration to the oxidative stress. For discussion, see the text.
