Genomic probability landscapes – unified structures for genomic analysis. Genomic sequence information, empirical sequence annotations and whole genome experimental data are converted into probability profiles along the genome primary sequence. Every profile consists of a primary probability for the feature at the given position and a secondary probability capturing the quality of the feature at the same position. New information can either be used to replace existing probability layers or added as new layer. The ensemble of information creates a probability landscape. Rescaling of probabilities can be easily achieved by vertical integration of the data base information.