Figure 5

Feature probability quality profile construction for experimental data. The probability assigned to genomic position n hereby does not only depend on the measure obtained in a given experimental condition C _q , but by the ensemble of all measures obtained for the observable located at n for a given technology (black arrows, left side of P-column). Likewise, the feature probability quality measures at n depend on all quality estimates (black arrows, right side of column). Those quality measures have a direct influence on the feature probability assigned to n, as discussed in the text (light grey arrows, right side). Finally, if data obtained under the same experimental condition are available for the same genomic location and where generated using different technologies, the P _n values can also be weighted according to their respective quality as determined by the associated P _Pn densities to account for technology dependent quality differences (dark grey arrow to the left). Please refer to the text for explanations.