Figure 1
From: Antimicrobial breakpoint estimation accounting for variability in pharmacokinetics
The left panel depicts two PK profiles with the same AUC (23.6 mg × h/L). The solid curve illustrates rapid absorption while the dashed curve corresponds to slower absorption. The right panel depicts the corresponding efficacy vs time curves, which still show the difference in the PK profiles of the left panel; this difference is translated into the values of the corresponding efficiency AUCW (17.45 vs 14.40 mg × h/L). The efficacy of the high absorption regime lasts almost throughout the therapeutic period (24 h) beyond the target efficacy of 0.8 mg.h/L, while the lower absorption regime barely reaches this target.