Figure 2
From: Antimicrobial breakpoint estimation accounting for variability in pharmacokinetics
Illustration of efficacy vs. concentration of the two groups of antimicrobial agents. The time-dependent microbial agent in the left panel has an efficiency of all or none, i.e. there is a threshold concentration above which the drug is considered to be fully effective, and below which it is non-effective. The performance of the concentration-dependent antimicrobial agent in the right panel is known to be proportional to concentration.