Antimicrobial breakpoint estimation accounting for variability in pharmacokinetics

Table 1 Report on the antibacterial agents for different activity patterns and methods*

	Year
Types or Methods	1970–1980	1981–1990	1991–2000	2001–2008	Drugs or parameters
Time-dependent	15	60	104	228	Beta-lactams Macrolides
Concentration-dependent	10	80	225	315	Aminoglycosides Fluoroquinolone
PK/PD-based methods	0	20	141	401	AUC₂₄/MIC Cmax/MIC C_BP T_>MIC

*The data reported in this Table have been collected using Ovid Medline^® with the following keywords: concentration-dependent; time-dependent; antibiotic; antimicrobial; PK/PD; breakpoint; efficacy.
Some antibacterial agents such as glycopeptides and some beta-lactams are referred to as being co-dependent.

ISSN: 1742-4682