Figure 1
Schematic diagram of the modified Lee-Heinrich model of wnt pathway. The modified model includes GSK3β phosphorylation, β-catenin non-GSK3β phosphorylation and degradtion denoted by reaction steps 18, 19, and 20, respectively, shown in blue. The reaction rate constants of these reaction steps are denoted kG/kG' (forward/backward reaction), kβ/kβ', and kβdeg, respectively. The added reaction steps at β-catenin* shown in the upper part of diagram are similar to the added reaction steps at β-catenin, denoted 19 and 20 (see text for detailed description). Numbering of other reaction steps is the same as in the original Lee-Heinrich model [2].