Figure 3

Time course of total concentrations of β-catenin and axin with transient wnt signaling. Solid line: the original Lee-Heinrich model. Other lines: k_G parameter was varied. Long dashed line: k_G = 0.1 min^-1. Short dashed line: k_G = 0.5 min^-1. Dashed-dotted line: k_G = 1 min^-1. Dotted line: k_G = 2 min^-1. The other kinetic parameters of added reaction steps, k_G' and k_β/k_β', were set equal to 1 and 0.1/1 min^-1, respectively. The time (in minutes) to maximum β-catenin level is marked for each line.