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Table 4 Steady-state concentrations of selected components without and with constant wnt signaling in the Lee-Heinrich and the present modified model

From: Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method

  W = 0 W = 1
Components Lee-Heinrich model Modified model Lee-Heinrich model Modified model
Dsha 0 0 90.9091 90.9091
(APC*/axin*/GSK3β) 0.00966 0.004742 0.001461 0.000656
(APC/axin/GSK3β) 0.00483 0.002362 0.000728 0.000327
(β-catenin*/APC*/axin*/GSK3β) 0.00202 0.001991 0.001862 0.001672
β-catenin* 1.00 0.983341 0.920076 0.825947
β-catenin 25.1 50.3766 153.028 305.759
Axin 0.000493 0.000492 0.000492 0.000492
GSK3β 50 25 50 25
GSK3β+   25   25
β-catenin+   5.03766   30.5759
  1. (see text for description).