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Table 4 Steady-state concentrations of selected components without and with constant wnt signaling in the Lee-Heinrich and the present modified model

From: Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method

 

W = 0

W = 1

Components

Lee-Heinrich model

Modified model

Lee-Heinrich model

Modified model

Dsha

0

0

90.9091

90.9091

(APC*/axin*/GSK3β)

0.00966

0.004742

0.001461

0.000656

(APC/axin/GSK3β)

0.00483

0.002362

0.000728

0.000327

(β-catenin*/APC*/axin*/GSK3β)

0.00202

0.001991

0.001862

0.001672

β-catenin*

1.00

0.983341

0.920076

0.825947

β-catenin

25.1

50.3766

153.028

305.759

Axin

0.000493

0.000492

0.000492

0.000492

GSK3β

50

25

50

25

GSK3β+

 

25

 

25

β-catenin+

 

5.03766

 

30.5759

  1. (see text for description).