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Figure 2 | Theoretical Biology and Medical Modelling

Figure 2

From: A tumor cord model for Doxorubicin delivery and dose optimization in solid tumors

Figure 2

Cell survival predicted as an exponential function of peak intracellular DOX concentration, using data from Kerr et al. [23]. Using this fit and the drug uptake model gives good agreement to a second data-set published in the same paper, but a rather poor agreement with a third. (A) Cell survival as a function of intracellular drug concentration. (B) Predicted cell survival versus the actual cell survival for cells exposed to different concentrations of DOX for 1 hour. (C) Predicted cell survival versus the actual cell survival for cells exposed to 5 μ m/ml of DOX for 15, 30, 45, and 60 minutes.

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