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Figure 7 | Theoretical Biology and Medical Modelling

Figure 7

From: Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination

Figure 7

Prediction of brain concentration of domperidone in WT (black line) and KO (black dashed line) mice using the MTB tissue model with passive transport, P-gp mediated efflux transport and additional efflux transport model for brain. Tissue concentration measured in WT mice (black lozenge) and KO mice (black circle) after IV administration of 5 mg/kg of domperidone. BLQ = Below Limit of Quantification.

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