Tissue | Vbla (mL/100 g tissue) | Stb (dm2/g tissue) | FP-gp, tc (-) | ClP-gp, td (L/min) | PSAte (L/min) | Clout, OTf (L/min) |
|---|
Brain
| 2g | 2h | 0.42 | 3.71 × 10-4 | 3.56 × 10-5 | 2.8 × 10-4 |
Heart
| 20i | 11.8j | 0.26 | 2.61 × 10-4 | 1.2 × 10-3 | --- |
- a Volume of blood in equilibrium with tissue
- b Exchange surface area
- c Relative fraction of mdr1a/1b mRNA expression in mice tissues compared to that in intestine, calculated from published data[6]. We calculated the ratio of multidrug resistance PCR product to that of β-actin in each organ and we related these ratios to that obtained in mice intestine tissue.
- d P-gp efflux clearance
- e Permeability-Surface area product
- f Parameter fitted to in vivo tissue concentrations
- g Intermediate value of published values: 1.6 uL/g brain [29]; 0.94 ug/g [30]; 3 ug/g [31]
- h Intermediate value of those published (1.50–2.40 dm2/g tissue) [32, 33]
- i Rat value [34]. Same ratio was found in guinea pigs [35]
- j Human data applied to mice: Surface area of cardiac capillaries [36]
