Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination

Table 4 Physico-chemical parameters of domperidone

Physico-chemical parameters	Values	References
Molecular weight	426	[48]
pKa	7.89	[48]
Octanol-Water partition coefficient (LogP)	3.35	EPIsuite [49]
Olive oil:water partition coefficient (LogP')	1.77^a	[27]
Fraction unbound to plasma protein (fu_p)	0.08	[50]
Blood:plasma ratio (BP)	0.92	[50]

ISSN: 1742-4682