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Table 2 Human ABCB1 amino acid residues shown to interact with ligands in site directed mutagenesis studies, corresponding Mus musculus ABCB1 amino acids shown to interact with ligand in X-ray crystal structure [20], and corresponding amino acid residues in ABCC4 and ABCC5.

From: Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure

TMH

Human ABCB1

Mus musculus ABCB1[20]

ABCC4

ABCC5

1

Leu65 [26]

Leu64

Glu103

Gln190

5

Ile306 [27, 35]

Ile302*

Ser328

Val410

6

Ile340 [33]

Ile336

Gly359

Asn441

6

Phe343 [21, 27]

Phe339

Arg362

Thr444

7

Phe728 [27]

Phe724

Ala727

Ser872

12

Val982 [33, 35]

Val978

Leu987

Val1137

  1. *) Not direct contact with ligand in Mus musculus ABCB1 X-ray crystal structure [20].