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Figure 5 | Theoretical Biology and Medical Modelling

Figure 5

From: Computational investigation of epithelial cell dynamic phenotype in vitro

Figure 5

Dysregulation of Axiom 5 ( ANOIKIS ) and its effect on ISEA growth and morphology. Axiom 5 dictates CELL DEATH when the decision-making CELL has in its neighborhood at least two CELLS and LUMINAL SPACE but no MATRIX. CELLS followed Axiom 5 with a parameter-controlled probability, p. Otherwise, the Axiom 5 precondition produced no CELL DEATH. Evasion of Axiom 5 changed ISEA1 and ISEA2 growth and structural characteristics in EMBEDDED CULTURES. (A-B) CELL counts at six levels of dysregulation are shown. Values are means of 100 Monte Carlo runs. CELL count increased monotonically with the severity of dysregulation. For ISEA2, the effects were less dramatic for larger p. (C) Dysregulation caused a nonlinear increase in both ISEA1 and ISEA2 CELL count measured after 50 simulation cycles.

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