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Figure 9 | Theoretical Biology and Medical Modelling

Figure 9

From: Computational investigation of epithelial cell dynamic phenotype in vitro

Figure 9

Dynamic phenotype: axiom usage by ISEA1 and ISEA2. Normalized axiom use frequencies are plotted versus simulation cycle. Left panels (A-C): ISEA1 use frequencies. Right panels (D-F): ISEA2 use frequencies. Top: axioms used most frequently. Middle: moderate use events. Bottom: Rare axiom use events. Axiom numbers in circles: the curves are normalized use frequencies averaged over 100 Monte Carlo runs. Axiom numbers in pentagons: the variance in average use frequency for the rarely used axioms was large; for clarity, trend lines are shown. In B and E, trend lines for Axiom 8 usage are magnified by a factor of 5. Raw data are provided in additional file 1: Supplemental Material. As simulations progressed and CYSTS matured, Axiom 11 (do nothing) was executed most frequently.

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