Figure 8
From: Mathematical framework for human SLE Nephritis: disease dynamics and urine biomarkers
Before flare interventions: simulations for patient 448. (A) Worsening of LN symptoms is greatly improved if the maintenance therapy is accompanied by an increase in anti-inflammatory therapy 2 months before flare, with close results when the decision is delayed for 6 more weeks (results not shown); s a = 0.4 A-units/day, 2 months before flare (solid curves); s a = 1.5 A-units/day, 2 months before flare (dashed curves). (B) When the increase of the anti-inflammatory treatment is delayed 2 weeks before flare, parallel therapeutic strategies aimed at faster removal of apoptotic cells greatly improves the outcome;, μ d = 0.03/day, and s a = 0.4 A-units/day at 2 weeks before flare (solid curves); μ d = 0.1/day, and s a = 1.5 A-units/day at 2 weeks before flare (dashed curves). All other parameters are as listed in Table 1 and Table 2.