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Figure 10 | Theoretical Biology and Medical Modelling

Figure 10

From: Glucose sensing in the pancreatic beta cell: a computational systems analysis

Figure 10

Steady-state simulations of parameters in response to changes of mitochondria content. We simultaneously changed all maximal rates of mitochondrial processes (JPYR, Jhres, Jph, Jhl, jTNADH, Juni, JNCa)- The arrow corresponds to the basal maximal rates and mitochondrial volume from Tables 2 and 3 (shown on axis as 1). A: [Ca2+]c at different glucose levels. B: Ψm, [PYR], [NADH]c and [ATP]c/[ADP]c at medium glucose level (9 mM); C: 2 Jglu, jPYR and JLDH at medium glucose level (9 mM). All other parameters were set as in Tables 2 and 3.

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