Figure 3
From: Glucose sensing in the pancreatic beta cell: a computational systems analysis
Comparison with muscle cell mitochondria. To compare β-cell and muscle cell mitochondria function we increased step by step the maximal rate of respiration (Vme, Equation 5) from basal β-cell level (arrow) (Table 3) and calculated the respiration rate (as Jhres), phosphorylation rate (as Jph), leak (Jhl) and Ψm in response to the maximal rate of proton pumping through the ETC (Vme). Coefficients for F1F0 ATPase activity were unchanged. [NADP]m (1570 μ M) and ADP (700 μ M) were set to be constant at high levels. Note the rate of ATP production (represented as Jph) increased significantly as well as Ψmwith an increase of the maximal rate of respiration (compare with Figure 2). All other parameters were set as in Figure 2.