From: Glucose sensing in the pancreatic beta cell: a computational systems analysis
Parameters | Symbol | Value | Units | Reference |
---|---|---|---|---|
Relative cytoplasmic volume per β-cell | Vi | 0.53 | Ul | [90] |
Relative mitochondrial volume per β-cell | Vmit | 0.06 | Ul | |
Relative mitochondrial matrix volume | Vmmit | 0.0144 | Ul | Ad |
Mitochondrial membrane capacitance for β-cells | Cmit | 1.812 | μM mV-1 | [136] |
Faraday's constant | F | 96484.6 | C mole-1 | Physical constant |
Valence of Ca2+ | ZCa | 2 | Ul | Physical constant |
Fraction of free Ca + in Mitochondria | fi | 0.01 | Ul | [5] |
Fraction of free Ca2+ in mitochondria | fm | 0.0003 | Ul | [28] |
Cytoplasmic Na+ concentration | [Na+]c | 10000 | μ M | [130] |
Mitochondrial Na+ concentration | [Na+]m | 5000 | μ M | [130] |
Thermal voltage (RT/F) (37°C) | Tv | 26.73 | mV | Physical constant |
Cellular adenine nucleotides concentration | At | 4000 | μ M | [5] |
Free pyridine nucleotides concentration in mitochondrial matrix | Ntm | 2200 | μ M | [123] |
Free pyridine nucleotides concentration in cytoplasm | Ntc | 2000 | μ M | Ad |