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Table 2 Standard physical and cellular parameter values (see text for explanations)

From: Glucose sensing in the pancreatic beta cell: a computational systems analysis

Parameters

Symbol

Value

Units

Reference

Relative cytoplasmic volume per β-cell

Vi

0.53

Ul

[90]

Relative mitochondrial volume per β-cell

Vmit

0.06

Ul

[90, 91]

Relative mitochondrial matrix volume

Vmmit

0.0144

Ul

Ad

Mitochondrial membrane capacitance for β-cells

Cmit

1.812

μM mV-1

[136]

Faraday's constant

F

96484.6

C mole-1

Physical constant

Valence of Ca2+

ZCa

2

Ul

Physical constant

Fraction of free Ca + in Mitochondria

fi

0.01

Ul

[5]

Fraction of free Ca2+ in mitochondria

fm

0.0003

Ul

[28]

Cytoplasmic Na+ concentration

[Na+]c

10000

μ M

[130]

Mitochondrial Na+ concentration

[Na+]m

5000

μ M

[130]

Thermal voltage (RT/F) (37°C)

Tv

26.73

mV

Physical constant

Cellular adenine nucleotides concentration

At

4000

μ M

[5]

Free pyridine nucleotides concentration in mitochondrial matrix

Ntm

2200

μ M

[123]

Free pyridine nucleotides concentration in cytoplasm

Ntc

2000

μ M

Ad

  1. Ul, unitless, Ad -Adjusted to fit glucose consumption rate and others conditions (see text).