Figure 2

Correlation networks and their analysis in a fictive model system. 2A: Depiction of the collaborative network in the cell infiltrate using significant Spearman's correlation coefficients (p < 0.05). Highly connected proteins with more than 3 significant correlations are marked in grey color; solid lines mark positive correlation coefficient, dotted line negative correlation coefficient. The analyzed tissue proteins include TGF-beta, MMP-2, TNF-R2, COX-2, AXL, c-myc, Ki67, beta-Catenin, ESDN, p53, Gas6, Notch 3, CD68, apoptosis -TUNEL, SMA, collagen type I - red pixel and type III - green pixel. Three therapy groups were compared; ethanol-controls, low dose GC and high dose GC. Figure 2B: Depiction of significant Spearman's correlations within a database of 20 variables, each consisting of 30 random data sets. Figure 2C: Depiction of significant Spearman's correlations within a fictive random database of 20 variables after introduction of a cluster, which included the variables 9 to 14 with equal numerical values, and which led to correlation coefficients of r = 1 between these variables.