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Figure 1 | Theoretical Biology and Medical Modelling

Figure 1

From: A generalized physiologically-based toxicokinetic modeling system for chemical mixtures containing metals

Figure 1

A schematic depiction of PBTK model structures for two common toxic metals (cadmium [33]and lead [45]), and a toxic metal compound (methylmercury [56]), as they have been implemented in the literature. The different physicochemical properties of the toxicants of concern have resulted in different structures (i.e. representations of the physiology) in the three models, thus limiting the usefulness of these formulations in assessing cumulative and/or comparative exposures and risks.

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